No verão de 1932, Wittgenstein alegou que o artigo recentemente publicado porCarnap “Linguagem Física como Linguagem Universal da Ciência” fez uso extensivo e semmenções das idéias do próprio Wittgenstein. Em uma carta a Schlick, ele se queixou que“em breve estaria em uma situação na qual seu próprio trabalho seria considerado mera-mente como uma versão requentada ou plágio do de Carnap”. Neste artigo, examino arelação entre o artigo de Carnap, posteriormente reimpresso como A Unidade da Ciência, eo tratamento dispensado por Wittgenstein, (...) nos primeiros sete capítulos das ObservaçõesFilosóficase outros escritos entre 1929-1932, a assuntos relacionados. (shrink)

No verão de 1932, Wittgenstein alegou que o artigo recentemente publicado porCarnap “Linguagem Física como Linguagem Universal da Ciência” fez uso extensivo e semmenções das idéias do próprio Wittgenstein. Em uma carta a Schlick, ele se queixou que“em breve estaria em uma situação na qual seu próprio trabalho seria considerado meramentecomo uma versão requentada ou plágio do de Carnap”. Neste artigo, examino arelação entre o artigo de Carnap, posteriormente reimpresso como A Unidade da Ciência, eo tratamento dispensado por Wittgenstein, nos (...) primeiros sete capítulos das ObservaçõesFilosóficas e outros escritos entre 1929-1932, a assuntos relacionados. (shrink)

Recent years have witnessed tremendous growth in the epidermal growth factor (EGF) family of peptide growth factors and the ErbB family of tyrosine kinases, the receptors for these factors. Accompanying this growth has been an increased appreciation for the roles these molecules play in tumorigenesis and in regulating cell proliferation and differentiation during development. Consequently, a significant question has been how diverse biological responses are specified by these hormones and receptors. Here we discuss several characteristics of hormone-receptor interactions and receptor (...) coupling that contribute to specificity: 1) a single EGF family hormone can bind multiple receptors; 2) a single ErbB family receptor can bind multiple hormones; 3) there are three distinct functional groups of EGF family hormones; 4) EGF family hormones can activate receptors in trans, and this heterodimerization diversifies biological responses; 5) ErbB3 requires a receptor partner for signaling; and 6) ErbB family receptors differentially couple to signaling pathways and biological responses. BioEssays 20:41–48, 1998. © 1998 John Wiley & Sons, Inc. (shrink)

Drawing on ten years of research on the unpublished Wittgenstein papers, Stern investigates what motivated Wittgenstein's philosophical writing and casts new light on the Tractatus and Philosophical Investigations. The book is an exposition of Wittgenstein's early conception of the nature of representation and how his later revision and criticism of that work led to a radically different way of looking at mind and language. It also explains how the unpublished manuscripts and typescripts were put together and why they often (...) provide better evidence of the development of his ideas than can be found in his published writing. In doing so, the book traces the development of a number of central themes in Wittgenstein's philosophy, including his conception of philosophical method, the picture theory of meaning, the limits of language, the application of language to experience, his treatment of private language, and what he called the "flow of life." Arguing that Wittgenstein's views are often much more simple (and more radical) than we have been led to believe, Wittgenstein on Mind and Language provides an overview of the development of Wittgenstein's philosophy and brings to light aspects of his philosophy that have been almost universally neglected. (shrink)

This chapter examines the developments that led from Wittgenstein’s early logical atomist view that all meaningful discourse can be analyzed into logically independent elementary propositions to his later philosophy. In 1929, Wittgenstein rejected logical atomism for a “logical holist” conception of language as composed of calculi, formal systems characterized by their constitutive rules. By the mid-1930s, he had rejected the model of a calculus, emphasizing that language is action within a social and natural context — more like a game than (...) a calculus — and that rule-governed behavior is dependent on a background of practices which cannot themselves be explicitly formulated as rules. The discussion of these central developments for the emergence of his later “practical holism” focuses on changes in his conception of the nature of measurement and the role of mind and mental processes in linguistic meaning. (shrink)

Unlike most books on Wittgenstein, Wittgenstein on Mind and Language begins from the initial articulation of his thoughts in his first drafts, conversations, and lectures, and attends closely to the process of revision that led to the Tractatus and Philosophical Investigations. This introductory chapter provides information about the nature of the Wittgenstein papers, summarizes the rationale for reading his work in this way, and outlines the reading of the development of Wittgenstein’s philosophy that this approach yields. This discussion on the (...) development of Wittgenstein’s thought emphasizes the role of his changing conception of the nature of experience and its relationship to the world, the closely related problem of the relationship between ordinary language and its analysis, his later conception of the role of analogies in generating — and dissolving — philosophical problems, the parallels with psychoanalysis, and the variety of philosophical methods employed in his later philosophical writing. There is also an overview of a central theme of the book as a whole: the contrast Wittgenstein drew between “ordinary” and “philosophical” ways of looking at things when he wrote the Tractatus, and how that contrast was transformed in his subsequent writing, focusing on his contrast between “primary” and “secondary” worlds and his notion of a “phenomenological language”. (shrink)

An analysis of the sources of Wittgenstein’s picture theory — which include not only his moment of insight on reading a magazine story about the use of models in a traffic court, but also the work of Russell, Hertz, and Boltzmann — provides the basis for an exploration of Wittgenstein’s articulation of a pictorial conception of representation in his wartime notebooks and its crystallization in the Tractatus. A discussion of Wittgenstein’s later criticism of the picture theory and his notion of (...) a “philosophical picture” illustrates the fundamental reversal in his transition to his later conception of philosophy: instead of taking literal pictures as a guide to the nature of meaning, he came to regard philosophical theories as akin to expressing an aesthetic preference for a certain style of representation. Wittgenstein’s treatment of factual language in the picture theory is related to his Tractarian approach to logical form, and the role of the show/say distinction in his early conception of logic and language. Particular attention is given to the difficulties generated by the idea that the conditions for the possibility of a given domain of discourse cannot be described in language, but must be shown by the form of words in question. (shrink)

This chapter argues that the ontology of the Tractatus is best understood as the consequence of Wittgenstein’s conception of logic and representation in general, and the postulate of the determinacy of sense in particular. Once it is recognized that Wittgenstein arrived at the idea of simple objects based on an abstract argument about the nature of complexes and analysis without providing any specific examples of such analyses, it is easy to see the need for caution in attributing any characteristics to (...) the objects over and above those demanded by Wittgenstein’s logicolinguistic commitments. Commentators have taken the Tractatus to be setting out a bewildering variety of highly specific views about the nature of objects. But the truth is that the book is so programmatic that its ontology can be elaborated in any number of ways. The final section of this chapter analyzes Wittgenstein’s treatment of the self in the Tractatus and his writing from the 1930s as a central example of the extreme tensions between the positivisistic doctrines stated in the Tractatus and the antipositivistic subtext it aims to convey or “show”: if the exoteric doctrine of the Tractatus is that there is no such thing as the subject of experience, the esoteric doctrine is that there is. This leads to a close reading of his proposal in the early 1930s that is considered a “subjectless” language as a way of clarifying the nature of experience, and his subsequent critique of the notions of the “metaphysical self” and the “visual world”. He had transmuted the difference between the first person and third person modes of speech into differences between two worlds and then had tried to put them back together again. (shrink)

The first section of this chapter presents a close reading of Wittgenstein’s “Remarks on Logical Form”, focusing on the conception of the relationship between language and experience, and the nature of the analysis of immediate experience that are set out there. Section two sets out an interpretation of what Wittgenstein meant when he said that he had rejected “phenomenological language” or “primary language” as his goal. Distinguishing between a weak and a strong sense of these terms shows how he could (...) have given up the goal of formulating a language that would amount to a complete analysis of immediate experience, yet retain the goal of finding ways of clarifying what we say about experience. Section three discusses Wittgenstein’s use of the analogy of the pictures on a roll of film in a movie projector and the pictures on a cinema screen for the relationship between world and experience. The final section analyzes how and why the analogy leads Wittgenstein to a paradoxical conception of immediate experience as a separate realm, “timeless” and “neighborless”, a conception of the “world as idea” that is supposedly inexpressible. (shrink)

In 1929, Wittgenstein made use of river imagery to convey the supposedly inexpressible thesis that all is in flux. However, he rejects this extreme thesis in manuscripts from the early 1930s and drafts of the Philosophical Investigations, affirming that one can step twice into the same river. His later discussion of the “stream of life” involves a return, in certain respects, to the river analogy, albeit in a very different key. Examining Wittgenstein’s changing use of this image casts light on (...) the continuities and discontinuities in the development of his philosophy. Wittgenstein’s argument that a private definition is impossible because ostension always depends on a “technique of use”, and his rejection of a positive theory of mind is clarified by examining some unusually explicit notes for a public lecture on private language. This material shows how the treatment of training and practice in the opening sections of the Philosophical Investigations is the basis for the subsequent discussion of both rule-following and privacy. (shrink)

Otto Weininger was one of the most controversial and widely read authors of fin-de-siècle Vienna. He was both condemned for his misogyny, self-hatred, anti-semitism and homophobia, as well as praised for his uncompromising and outspoken approach to gender and morality. For Wittgenstein Weininger was a 'remarkable genius'. He repeatedly recommended Weininger's Sex and Character to friends and students and included the author on a short list of figures who had influenced him. The purpose of this new collection of essays is (...) to explore the various ways in which Wittgenstein absorbed and responded to Weininger's ideas. Written by an international team of experts on Wittgenstein and Weininger, the volume is especially timely in the light of recent translations of Weininger's work and will appeal to anyone interested in the history of 20th century philosophy, and the literary and cultural history of fin-de-siècle Vienna. (shrink)

This chapter contains section titled: Introduction: Baker on the Private Language Argument Strawson's and Malcolms Interpretations of the Beetle Story Pitcher's, Cook's, and Donagan's Interpretations of the Beetle Story Cohen's Repudiation of the Beetle Story Hacker's and Baker's Interpretations of the Beetle Story.

This chapter explores themes like freedom of expression and what makes for a democratic society by examining characters and situations collected from a variety of South Park episodes. It discusses some of the important democratic concepts and arguments presented by thinkers like Karl Popper and Thomas Jefferson. Of particular interest are the roles of free expression and unfettered intellectual inquiry—even when they're offensive—in a democratic society. Finally, the author speaks that Popper and others understand this sort of freedom to be (...) absolutely essential to a healthy democracy. (shrink)

Online social networks (OSN) have become a part of our daily lives whether they are used for socialization and communication or to promote business interests. OSN have become an important tool for businesses to advertise, create brand awareness, and promote their products and services. Business use of OSN for advertising purposes is highly reliant on targeted ads which display advertisements to OSN users based on their demographics and use of OSN, apps, and websites. Thus, one of the most valuable commodities (...) of OSN is the population of users and the information they share. To investigate the relationship between OSN site use, use of privacy settings, and how they relate to profile disclosure, a model is built based on the theory of reasoned action and the privacy calculus model. To validate the model, a survey is conducted and the results are analyzed with partial least squares. Risk and benefit were both shown to be significant antecedents of attitude. Both attitude and subjective norm, from the theory of reasoned action model, significantly affected OSN site use, while omitting intentions. OSN site use was significantly related to both profile disclosure and use of privacy settings. Last, use of privacy settings significantly affected profile disclosure. These results imply that use of privacy settings does not decrease the rate of disclosure. Giving users tools to protect their private information is important in protecting the privacy of OSN users, and it will lead to increases in safe disclosure of information helping OSN target ads effectively. (shrink)

November 28-December 1, 1994, Denver, Colorado NIPS is the longest running annual meeting devoted to Neural Information Processing Systems.

Binding of antigen or lectin to the surface of a T lymphocyte initiates a complex sequence of events which result in both T cell proliferation and the acquisition of immunologic functions. This complex sequence of events is most likely programmed and precisely timed by a series of contingent gene activations in which one member of this series activates the next. The two most obvious examples of these stages are the set of genes activated when antigen interacts with the antigen receptor (...) and the set of genes activated when IL‐2 interacts with its receptor. However, it is likely that several other parallel pathways of gene activation are necessary to bring about T‐cell division. An example would be the antigen‐induced activation of the c‐myc gene, which in turn is likely to be involved in regulating an additional group of genes not directly controlled by either IL‐2 or antigen. A fundamental understanding of T‐lymphocyte activation necessitates identification of the factors involved in initiating each of these contingent levels of gene activation. (shrink)

David Estlund’s Democratic Authority develops a novel doctrine of “normative consent,” according to which the nonconsent of those with a duty to consent is null. This article suggests that this doctrine can be defended by confining it to contexts involving consent to an authority, which raise distinctive normative challenges, but argues that Estlund’s attempt to deploy the doctrine fails, for it does not provide convincing reasons to think that citizens have any duty to consent. In closing, the article suggests (...) that the doctrine of normative consent might yet do some useful work in a quite different theoretical setting. (shrink)

Ludwig Wittgenstein is one of the most important, influential, and often-cited philosophers of the twentieth century, yet he remains one of its most elusive and least accessible. The essays in this volume address central themes in Wittgenstein's writings on the philosophy of mind, language, logic, and mathematics. They chart the development of his work and clarify the connections between its different stages. The contributors illuminate the character of the whole body of work by keeping a tight focus on some key (...) topics: the style of the philosophy, the conception of grammar contained in it, rule-following, convention, logical necessity, the self, and what Wittgenstein called, in a famous phrase, 'forms of life'. (shrink)

In this new introduction to a classic philosophical text, David Stern examines Wittgenstein's Philosophical Investigations. He gives particular attention to both the arguments of the Investigations and the way in which the work is written, and especially to the role of dialogue in the book. While he concentrates on helping the reader to arrive at his or her own interpretation of the primary text, he also provides guidance to the unusually wide range of existing interpretations, and to the (...) reasons why the Investigations have inspired such a diversity of readings. Following closely the text of the Investigations and meant to be read alongside it, this survey is accessible to readers with no previous background in philosophy. It is well-suited to university-level courses on Wittgenstein, but can also be read with profit by students in other disciplines. (shrink)

Medical theory and practice in the second half of the 20th century were transformed by the idea of risk, and, in particular, by the concept of the "risk factor." Many historians have described how the concept of the risk factor emerged in the actuarial science of the life insurance industry in the early 20th century and entered medicine through the Framingham Heart Study, specifically with its July 1961 article, "Factors of Risk in the Development of Coronary Heart Disease," in the (...) Annals of Internal Medicine. This story, while plausible, is incorrect.New techniques of digital history enable a new kind of research: full-text searching of publications in medicine, public health, and other... (shrink)

Book reviewed in this article: Down the Slippery Slope: Arguing in Applied Ethics. By David Lamb.

Originally conceived as a forty-page conclusion to Hacker’s twenty years of work on the monumental four-volume Analytical Commentary on the Philosophical Investigations, this book “rapidly assumed a life of its own”. A major contribution to the history of analytic philosophy, this substantial volume delivers even more than the title promises. The eight chapters are best approached as a six-chapter book, itself some 220 pages long, on Wittgenstein’s contribution to twentieth-century philosophy, followed by a two-chapter, 120-page epilogue about how and why (...) his influence has waned. The first six chapters provide an encyclopedic summary of the fruits of Hacker’s research on Wittgenstein’s writing, an immensely learned account of British philosophy from the turn of the century to the 1970s, and a detailed account of Wittgenstein’s reception by Oxford, Cambridge, and the Vienna Circle. The book’s closing chapters, “Post-positivism in the United States and Quine’s Apostasy” and “The Decline of Analytic Philosophy,” polemically argue that Quine’s philosophy, and the post-Quinean naturalism prevalent in Anglo-American philosophy today, amount to such a decisive break with the analytic tradition, as Hacker conceives of it, that they should not be counted as “analytic.”. (shrink)

Training in ethics and professionalism is a fundamental component of residency education, yet there is little empirical information to guide curricula. The objective of this study is to describe empirically derived ethics objectives for ethics and professionalism training for multiple specialties. Study design is a thematic analysis of documents, semi-structured interviews, and focus groups conducted in a setting of an academic medical center, Veterans Administration, and community hospital training more than 1000 residents. Participants were 84 informants in 13 specialties including (...) residents, program directors, faculty, practicing physicians, and ethics committees. Thematic analysis identified commonalities across informants and specialties. Resident and nonresident informants identified consent, interprofessional relationships, family interactions, communication skills, and end-of-life care as essential components of training. Nonresidents also emphasized formal ethics instruction, resource allocation, and self-monitoring, whereas residents emphasized the learning environment and resident-attending interactions. Conclusions are that empirically derived learning needs for ethics and professionalism included many topics, such as informed consent and resource allocation, relevant for most specialties, providing opportunities for shared curricula and resources. (shrink)

Drawing on recent work on the nature of the numbering system of the _Tractatus_ and Wittgenstein’s use of that system in his composition of the _Prototractatus_, the paper sets out the rationale for the online tool called__ __ The University of Iowa Tractatus Map. The map consists of a website with a front page that links to two separate subway-style maps of the hypertextual numbering system Wittgenstein used in his _Tractatus_. One map displays the structure of the published _Tractatus_; the (...) other lays out the structure of the _Prototractatus_. The site makes available the full text of the German and the two canonical English translations.__ __While we envisage the map as a tool that we would like a wide variety of readers to find helpful, we argue that our website amounts to a radically new edition of Wittgenstein’s early masterpiece, with far-reaching implications for the interpretation of that text. In particular, we claim that our visually compelling presentation of the book’s overall structure delivers on Wittgenstein’s cryptic claim in a letter to his publisher that it is the numbers that “make the book surveyable and clear”. (shrink)